Endocrine Abstracts

Introduction: Type 2 diabetes mellitus (T2DM) frequently associates with increasing multi-morbidity/treatment complexity. Some headway has been made to identify genetic and non-genetic risk factors for T2DM. However longitudinal clinical histories of individuals both before and after diagnosis of T2DM are likely to provide additional insight into both diabetes aetiology/further complex trajectory of multi-morbidity.Methods: This study utilised diabetes p...

Context: Approximately 15% of people with hypothyroidism remain symptomatic despite treatment. The Thr92Ala substitution in DIO2, may influence T3 tissue levels.Methods: We assessed HADS anxiety and depression scores in HUNT2 in 50,901 individuals (6,687 homozygous for Thr92Ala) of whom 1,480 had a history of levothyroxine use (180 homozygous for Thr92Ala). Anxiety and depression caseness (score>=8) by levothyroxine and Thr92Ala status was a...

Context: Up to 15% of people with hypothyroidism remain symptomatic despite treatment with levothyroxine. A proportion of these utilise combination thyroid hormone replacement, T3 monotherapy and desiccated thyroid extract (DTE). We sought to explore thyroid hormone profiles in these patients.Methods: We performed hourly blood tests (8.30am-4.30pm) to assess TSH, T3 and T4 levels in 49 individuals (n =14 combination thyroid hormone replacement, ...

Context: Approximately 10% of patients on levothyroxine remain symptomatic despite restoration of biochemical euthyroidism. Some therefore utilise alternatives to levothyroxine monotherapy including combination thyroid hormone replacement, T3 monotherapy and desiccated thyroid extract (DTE). We examined thyroid hormone profiles in these patients.Methods: We examined 49 individuals 14 on combination thyroid hormone replac...